Overview

Lumeda Inc. is a medical technology company advancing photodynamic therapy (PDT) as an adjuvant treatment for patients with non-small cell lung cancer (NSCLC) and other thoracic malignancies.  Lumeda’s breakthrough light dosimetry product called DigiLum™  is designed to activate a photosensitizer drug and deliver PDT  to reduce the recurrence of cancer and enhance antitumor immunity.  DigiLum™ applies advanced photonics and proprietary Artificial Intelligence (AI) software to enable thoracic surgeons to control dosimetry, reduce treatment time and capture data for future treatment planning.

PDT is a two-stage cancer treatment that involves a photosensitizer drug that preferentially collects within cancer cells and then produces cell death and tumor ablation upon light activation.  PDT has been shown to significantly improve patient progression-free and overall survival when applied intraoperatively following surgical lung cancer tumor resection.  In pre-clinical studies PDT has also been shown to alter the immune contexture of tumors to make them more receptive to immunotherapy. 

The photosensitizer drug is highly effective and safe with minimal toxicity.  The DigiLum™ light dosimetry system is based on a novel PDT device innovation demonstrated by Roswell Park Comprehensive Cancer Center that delivers and monitors laser light directly in contact with target tissue.  This enables a system design and simplified treatment procedure that is highly automated for ease of use with high efficacy and repeatability and overcomes several obstacles that have limited use of PDT for other diseases and anatomical sites.

Our DigiLum™ system is designed to be a safe and effective therapy with minimal side effects to address disease recurrence in NSCLC tumor resection.  It also has application for the large unmet need in treating pleural disease, in which there are currently no effective therapies for treating patients with NSCLC with pleural dissemination or malignant pleural mesothelioma.  The addition of PDT in lung-sparing surgical intervention of these diseases has been shown to improve survival and quality of life in these patients.  DigiLum™ has the potential to give the treating physician a compelling treatment option in combination with other therapies.